abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Piazza G

更新日期：2018-12-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by activating ubiquitous protease plasmin in many important physiological processes. The system components include uPA, plasminogen activator inhibitors (PAIs) and uPA receptor (uPAR). Besides its role in physiological processes, u...

journal_title：Thrombosis and haemostasis

authors： Madunić J

更新日期：2018-12-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte-platelet complexes (MPCs). Here, we analysed MPC in vivo and in vitro and investigated the abilities of different monocyte subclasses to form MPC, the characteristics of the cells involved in MPC fo...

journal_title：Thrombosis and haemostasis

authors： Loguinova M,Pinegina N,Kogan V,Vagida M,Arakelyan A,Shpektor A,Margolis L,Vasilieva E

更新日期：2018-11-01 00:00:00

abstract：:In the AMPLIFY clinical trial, apixaban was non-inferior to warfarin plus subcutaneous enoxaparin bridge therapy in the treatment of acute venous thromboembolism (VTE) and was associated with significantly less bleeding. This study evaluated their comparative effectiveness and safety in routine clinical practice. A ma...

journal_title：Thrombosis and haemostasis

authors： Weycker D,Li X,Wygant GD,Lee T,Hamilton M,Luo X,Vo L,Mardekian J,Pan X,Burns L,Atwood M,Hanau A,Cohen AT

更新日期：2018-11-01 00:00:00

abstract：:Primary immune thrombocytopaenia (ITP) is the most common haemorrhagic disease. Although most patients respond initially to mainstream therapies, such as corticosteroids, immunosuppressants or rituximab, a large proportion of patients fail to respond or relapse. These treatments only affect B lymphocytes or short-live...

journal_title：Thrombosis and haemostasis

authors： Li G,Wang S,Li N,Liu Y,Feng Q,Zuo X,Li X,Hou Y,Shao L,Ma C,Gao C,Hou M,Peng J

更新日期：2018-10-01 00:00:00

abstract：:Oral anticoagulants used for the primary treatment of venous thromboembolism (VTE) include warfarin and the more recently introduced direct oral anticoagulants (DOACs), including rivaroxaban, apixaban, dabigatran and edoxaban. Information on the comparative safety of these medications in routine clinical practice is l...

journal_title：Thrombosis and haemostasis

authors： Roetker NS,Lutsey PL,Zakai NA,Alonso A,Adam TJ,MacLehose RF

更新日期：2018-09-01 00:00:00

abstract：:Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such experiments into quantitative variables describing platelet movements ...

journal_title：Thrombosis and haemostasis

authors： Tunströmer K,Faxälv L,Boknäs N,Lindahl TL

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND: Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the r...

journal_title：Thrombosis and haemostasis

authors： Crombag GAJC,Spronk HM,Nelemans P,Schreuder FHBM,Truijman MTB,van Dijk AC,de Rotte AAJ,Liem MI,Daemen MJAP,van der Steen AFW,Mess WH,Nederkoorn PJ,Hendrikse J,van der Lugt A,Wildberger JE,Ten Cate H,van Oostenbrugge RJ,

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND: Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors...

journal_title：Thrombosis and haemostasis

authors： Coelho-Lima J,Mohammed A,Cormack S,Jones S,Das R,Egred M,Panahi P,Ali S,Spyridopoulos I

更新日期：2018-07-01 00:00:00

abstract：:A disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic fun...

journal_title：Thrombosis and haemostasis

authors： van der Vorst EPC,Weber C,Donners MMPC

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

journal_title：Thrombosis and haemostasis

authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

更新日期：2018-07-01 00:00:00

abstract：:Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

journal_title：Thrombosis and haemostasis

authors： Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

更新日期：2018-06-01 00:00:00

abstract：:Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges ...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Schwameis M,Gilbert JC,Schörgenhofer C,Jilma B

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recen...

journal_title：Thrombosis and haemostasis

authors： Kibler M,Marchandot B,Messas N,Caspar T,Vincent F,Von Hunolstein JJ,Grunebaum L,Reydel A,Rauch A,Crimizade U,Kindo M,Hoang Minh T,Trinh A,Petit-Eisenmann H,De Poli F,Leddet P,Jesel L,Ohlmann P,Susen S,Van Belle E,

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with a short half-life and a fast onset and offset of effect. Before elective surgery, discontinuation is recommended with an interval of at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve a residual RXA...

journal_title：Thrombosis and haemostasis

authors： Kaserer A,Schedler A,Jetter A,Seifert B,Spahn DR,Stein P,Studt JD

更新日期：2018-05-01 00:00:00

abstract：:Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the rel...

journal_title：Thrombosis and haemostasis

authors： Reddel CJ,Pennings GJ,Curnow JL,Chen VM,Kritharides L

更新日期：2018-04-01 00:00:00

abstract：:The effect of additional treatments combined with conventional therapy on pregnancy outcomes was examined in high-risk primary antiphospholipid syndrome (PAPS) patients to identify the most effective treatment strategy. The study's inclusion criteria were (1) positivity to lupus anticoagulant alone or associated with ...

journal_title：Thrombosis and haemostasis

authors： Ruffatti A,Tonello M,Hoxha A,Sciascia S,Cuadrado MJ,Latino JO,Udry S,Reshetnyak T,Costedoat-Chalumeau N,Morel N,Marozio L,Tincani A,Andreoli L,Haladyj E,Meroni PL,Gerosa M,Alijotas-Reig J,Tenti S,Mayer-Pickel K,Simc

更新日期：2018-04-01 00:00:00

abstract：:Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) wi...

journal_title：Thrombosis and haemostasis

authors： Furio E,García-Fuster MJ,Redon J,Marques P,Ortega R,Sanz MJ,Piqueras L

更新日期：2018-03-01 00:00:00

abstract：:Third-generation P2Y12 inhibitors (prasugrel, ticagrelor) are recommended in acute myocardial infarction (AMI). We aimed to evaluate the efficacy and safety of third-generation P2Y12 inhibitors in East Asian AMI patients. From the Korean AMI Registry, 9,355 patients who received dual antiplatelet agent (aspirin with c...

journal_title：Thrombosis and haemostasis

authors： Kang J,Han JK,Ahn Y,Chae SC,Kim YJ,Chae IH,Hur SH,Seong IW,Chae JK,Cho MC,Seung KB,Jeong MH,Yang HM,Park KW,Kang HJ,Koo BK,Kim HS,investigators for Korea Acute Myocardial Infarction Registry-National Institute of Health

更新日期：2018-03-01 00:00:00

abstract：:The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which may delay gastric transit and reduce DAPT absorption. We sought to assess the effect of mo...

journal_title：Thrombosis and haemostasis

authors： Farag M,Spinthakis N,Srinivasan M,Sullivan K,Wellsted D,Gorog DA

更新日期：2018-03-01 00:00:00

abstract：:Antithrombin (AT) activity tests are used for diagnosing hereditary AT deficiency, a main genetic determinant of thrombophilia. They are either based on inhibition of thrombin (FIIa) or activated factor X (FXa). FXa-based assays have been suggested to be preferable to FIIa-based assays due to their higher sensitivity ...

journal_title：Thrombosis and haemostasis

authors： Rühl H,Reda S,Müller J,Oldenburg J,Pötzsch B

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

journal_title：Thrombosis and haemostasis

authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

更新日期：2018-01-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:Patients with intermediate-risk pulmonary embolism (PE) may, depending on the method and cut-off values used for definition, account for up to 60% of all patients with PE and have an 8% or higher risk of short-term adverse outcome. Although four non-vitamin K-dependent direct oral anticoagulants (NOACs) have been appr...

journal_title：Thrombosis and haemostasis

authors： Klok FA,Ageno W,Barco S,Binder H,Brenner B,Duerschmied D,Empen K,Faggiano P,Ficker JH,Galiè N,Ghuysen A,Held M,Heydenreich N,Huisman MV,Jiménez D,Kozak M,Lang IM,Lankeit M,Münzel T,Petris A,Pruszczyk P,Quitzau K

更新日期：2017-12-01 00:00:00

abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

journal_title：Thrombosis and haemostasis

authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

更新日期：2017-11-01 00:00:00

abstract：:Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncont...

journal_title：Thrombosis and haemostasis

authors： Fender AC,Rauch BH,Geisler T,Schrör K

更新日期：2017-11-01 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

journal_title：Thrombosis and haemostasis

authors： Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

更新日期：2017-10-05 00:00:00

abstract：:Two new strategies for interpreting D-dimer results have been proposed: i) using a progressively higher D-dimer threshold with increasing age (age-adjusted strategy) and ii) using a D-dimer threshold in patients with low clinical probability that is twice the threshold used in patients with moderate clinical probabili...

journal_title：Thrombosis and haemostasis

authors： Takach Lapner S,Julian JA,Linkins LA,Bates S,Kearon C

更新日期：2017-10-05 00:00:00

abstract：:Factor Xa (fXa)-inhibitors are as effective and safer than vitamin-K-antagonists (VKA) in the treatment of venous thromboembolism (VTE). We previously classified the severity of clinical presentation and course of all major bleeding events from the EINSTEIN, AMPLIFY and HOKUSAI-VTE trials separately. The current aim w...

journal_title：Thrombosis and haemostasis

authors： Bleker SM,Brekelmans MPA,Eerenberg ES,Cohen AT,Middeldorp S,Raskob G,Büller HR

更新日期：2017-10-01 00:00:00

abstract：:The interdependence of the predictive accuracy of serum osteoprotegerin (OPG) and von Willebrand factor (vWF) levels for long-term cardiovascular outcomes has not been investigated so far. This was a prospective observational cohort study in 361 patients with coronary artery disease undergoing percutaneous coronary in...

journal_title：Thrombosis and haemostasis

authors： Siller-Matula J,Lang IM,Schoergenhofer C,Roest M,Jilma B

更新日期：2017-08-30 00:00:00

abstract：:The clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed ...

journal_title：Thrombosis and haemostasis

authors： Cubedo J,Blasco A,Padro T,Ramaiola I,Juan-Babot O,Goicolea J,Fernández-Díaz JA,Oteo JF,Badimon L

更新日期：2017-08-30 00:00:00

abstract：:Existing clinical scores do not perform well in predicting bleeding in elderly patients with acute venous thromboembolism (VTE). We sought to derive an easy-to-use clinical score to help physicians identify elderly patients with VTE who are at high-risk of bleeding during extended anticoagulation (>3 months). Our deri...

journal_title：Thrombosis and haemostasis

authors： Seiler E,Limacher A,Mean M,Beer HJ,Osterwalder J,Frauchiger B,Righini M,Aschwanden M,Matter CM,Banyai M,Kucher N,Staub D,Lämmle B,Rodondi N,Squizzato A,Aujesky D

更新日期：2017-08-24 00:00:00

abstract：:Congenital factor VII (FVII) deficiency is a rare bleeding disorder caused by mutations in F7 gene with autosomal recessive inheritance. A clinical heterogeneity with poor correlation with FVII:C levels has been described. It was the objective of this study to identify genetic defects and to evaluate their relationshi...

journal_title：Thrombosis and haemostasis

authors： Quintavalle G,Riccardi F,Rivolta GF,Martorana D,Di Perna C,Percesepe A,Tagliaferri A,Ad-Hoc Study Group.

更新日期：2017-08-01 00:00:00

abstract：:The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused ...

journal_title：Thrombosis and haemostasis

authors： Mojica Muñoz AK,Jamasbi J,Uhland K,Degen H,Münch G,Ungerer M,Brandl R,Megens R,Weber C,Lorenz R,Siess W

更新日期：2017-08-01 00:00:00

abstract：:Carboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin. The aim of this study was to investigate and characterise the time course o...

journal_title：Thrombosis and haemostasis

authors： Leenaerts D,Aernouts J,Van Der Veken P,Sim Y,Lambeir AM,Hendriks D

更新日期：2017-07-26 00:00:00

abstract：:Deep-vein thrombosis (DVT) is a common condition that often leads to pulmonary thromboembolism (VTE) and death. The role of prostaglandin-endoperoxide synthase (PTGS)2 in arterial thrombosis has been well established, whereas its impact in venous thrombosis remains unclear. Here, we showed that PTGS2 deletion predispo...

journal_title：Thrombosis and haemostasis

authors： Amadio P,Tarantino E,Sandrini L,Tremoli E,Barbieri SS

更新日期：2017-07-26 00:00:00

abstract：:Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence du...

journal_title：Thrombosis and haemostasis

authors： Stroo I,Zeerleder S,Ding C,Luken BM,Roelofs JJTH,de Boer OJ,Meijers JCM,Castellino FJ,van 't Veer C,van der Poll T

更新日期：2017-07-26 00:00:00